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达泊西汀

英文名: Dapoxetine

CAS: 119356-77-3      分子式: C21H23NO

分子量: 305.41300

别名:


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描述

Dapoxetine, marketed as Priligy and Westoxetin, among and other brands, is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay. As a member of selective serotonin reuptake inhibitor (SSRI) family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant. Originally created by Eli Lilly pharmaceutical company, dapoxetine was sold to Johnson & Johnson in 2003 and submitted as a New Drug Application to the Food and Drug Administration (FDA) for the treatment of PE in 2004. Dapoxetine has been sold in several European and Asian countries, and lately in Mexico. In the US, dapoxetine has been stuck in phase III development since 2003. However, it is expected to be marketed soon. In 2012, Menarini acquired the rights to commercialise Priligy in Europe, most of Asia, Africa, Latin America and the Middle East.

基本信息
英文名:
Dapoxetine
CAS号.:
119356-77-3
别名:
(1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine; Priligy; Dapoxetina; Dapoxetinum;
分子式:
C21H23NO
分子量:
305.41300
PSA:
12.47000
LogP:
4.91160
物化属性
外观:
White to off-white crystalline powder
密度:
1.081 g/cm3
熔点:
沸点:
454.4ºC at 760mmHg
闪点:
132.6ºC
储存条件:
安全信息
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2922199090
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