7-甲氧基-6-(3-吗啉-4-基丙氧基)喹唑啉-4(3H)-酮
英文名: 7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one
CAS: 199327-61-2 分子式: C16H21N3O4
分子量: 319.35600
别名:
Gefitinib impurity 5 is an impurity of Gefitinib. Gefitinib is an effective selective EGFR tyrosine kinase inhibitor with oral activity, with an IC50 of 33 nM. Gefitinib selectively inhibits the growth of EGF-stimulated tumor cells (IC50 is 54 nM), and blocks EGFR autophosphorylation in EGF-stimulated tumor cells. Gefitinib can also induce autophagy. Gefitinib has anti-tumor activity.